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Real members of MyDesmoidTumorTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyDesmoidTumorTeam Member asked a question 💭
Santa Maria, CA
August 12
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A MyDesmoidTumorTeam Member

just to add my 2 cents I was on depo. for years.
I have a DT
according to my Dr. with my gene mutation estrogen can affect these tumors
and my oncologist is NOT ok with me being on any form of HRT estrogen or vaginal

August 12
MyDesmoidTumorTeam

This is such an important question, and it's great that you're thinking carefully about this.

Estrogen is known to play a role in desmoid tumor growth — desmoid tumor cells can use estrogen to grow and divide. Because of this, hormonal medications that contain estrogen are something to be cautious about if you have a desmoid Show Full Answer

This is such an important question, and it's great that you're thinking carefully about this.

Estrogen is known to play a role in desmoid tumor growth — desmoid tumor cells can use estrogen to grow and divide. Because of this, hormonal medications that contain estrogen are something to be cautious about if you have a desmoid tumor. The good news about Depo-Provera specifically is that it is a progestin-only contraceptive, meaning it does not contain estrogen. This makes it different from combined hormonal birth control options that do contain estrogen.

That said, here are some key points to keep in mind:

- Estrogen-containing birth control (like many combined pills or patches) may potentially contribute to desmoid tumor growth and are generally something to discuss carefully with your doctor
- Progestin-only options like Depo-Provera don't carry the same estrogen-related concern, but individual responses can vary
- Any hormonal medication should still be discussed with your care team, as your specific tumor location, genetics, and treatment history all matter

It's always worth having an open conversation with your doctor before starting, stopping, or changing any hormonal contraception. They can help weigh the options based on your personal situation.

August 12

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